Related Experiment Video
Updated: Apr 1, 2026
06:28
Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
4.6K
Reproductive outcome in globozoospermic men: update and prospects
L Chansel-Debordeaux1, S Dandieu, S Bechoua2
1Service de Biologie de la Reproduction-CECOS, CHU de Bordeaux, Centre Aliénor d'Aquitaine, Bordeaux, France.
Andrology
|October 8, 2015
Summary
Globozoospermia, a severe male infertility cause, often results in low fertilization rates. Oocyte activation techniques significantly improve pregnancy rates for affected couples undergoing assisted reproduction.
Area of Science:
- Reproductive Medicine
- Andrology
- Genetics
Background:
- Infertility affects 15% of couples, with male factors contributing 20% of cases.
- Globozoospermia is a rare teratozoospermia type causing poor pregnancy outcomes.
- Understanding its morphology, physiology, and genetics is crucial.
Purpose of the Study:
- To review reproductive outcomes in globozoospermic patients.
- To evaluate assisted reproduction techniques for globozoospermia.
- To identify strategies for improving pregnancy rates.
Main Methods:
- Comprehensive literature review (20 years, English/French) using PubMed/Medline, ScienceDirect, Scopus.
- Analysis of 45 publications detailing 172 assisted reproduction attempts (ICSI/IMSI).
- Inclusion of data on oocyte activation and outcomes.
Main Results:
- Reviewed 28 deliveries and 34 children from globozoospermic patients.
- Observed persistently low fertilization rates after conventional ICSI.
- Identified oocyte activation, particularly with calcium ionophore, as a key factor.
Conclusions:
- Oocyte activation significantly enhances pregnancy rates in globozoospermia cases.
- Further research into globozoospermia pathogenesis is needed.
- Recombinant phospholipase C zeta (PLCζ) shows promise for future treatments.
Related Concept Videos
01:23Infertility in Males
683
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
683
01:41Spermatogenesis
124.7K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
124.7K
01:28Infertility in Females
5.0K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
5.0K
01:22Sperm Structure and Semen Composition
14.3K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
14.3K
01:11Testing a Claim about Mean: Known Population SD
3.4K
A complete procedure of testing the hypothesis about a population mean is explained here.
Estimating a population mean requires the samples to be distributed normally. The data should be collected from the randomly selected samples having no sampling bias. The sample size needed to be higher than 30, and most importantly, the population standard deviation should be already known.
In most realistic situations, the population standard deviation is often unknown, but in rare circumstances, when it...
Estimating a population mean requires the samples to be distributed normally. The data should be collected from the randomly selected samples having no sampling bias. The sample size needed to be higher than 30, and most importantly, the population standard deviation should be already known.
In most realistic situations, the population standard deviation is often unknown, but in rare circumstances, when it...
3.4K
01:24In Vitro Fertilization
1.4K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.4K