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Published on: June 15, 2018
Long Non-Coding RNAs as Master Regulators in Cardiovascular Diseases
Krystal Archer1, Zuzana Broskova2, Ahmed S Bayoumi3
1Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA. karcher@gru.edu.
Insights
Long non-coding RNAs (lncRNAs) are key regulators of gene expression and show promise as novel therapeutic targets for cardiovascular diseases. Their aberrant expression is linked to heart conditions, and circulating lncRNAs may serve as diagnostic biomarkers.
Area of Science:
- Cardiovascular Medicine
- Molecular Biology
- Genetics
Background:
- Cardiovascular disease remains the leading cause of death in the US, with limited survival improvements despite new therapeutics.
- Understanding novel molecular mechanisms, like non-coding RNAs, is crucial for advancing cardiovascular medicine.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in gene expression.
Purpose of the Study:
- To review recent discoveries linking lncRNAs to cardiovascular diseases.
- To explore the molecular interactions of lncRNAs in cardiovascular pathogenesis.
- To assess the potential of circulating lncRNAs as biomarkers for heart disease diagnosis and prognosis.
Main Methods:
- Literature review of recent studies on lncRNAs and cardiovascular diseases.
- Analysis of molecular mechanisms involving lncRNAs in heart conditions.
- Evaluation of the diagnostic and prognostic utility of circulating lncRNAs.
Main Results:
- lncRNAs play critical roles in modulating the initiation and progression of cardiovascular diseases.
- Aberrant lncRNA expression is associated with the pathogenesis of conditions like ischemic heart failure.
- Circulating lncRNAs show potential as biomarkers for cardiovascular disease diagnosis and prognosis.
Conclusions:
- lncRNAs represent a promising area for novel therapeutic strategies in cardiovascular medicine.
- Further research into lncRNA functions and interactions is warranted for developing targeted treatments.
- Circulating lncRNAs hold significant potential for non-invasive diagnosis and prognosis of heart disease.
Abstract:
Cardiovascular disease is the leading cause of death in the United States, accounting for nearly one in every seven deaths. Over the last decade, various targeted therapeutics have been introduced, but there has been no corresponding improvement in patient survival. Since the mortality rate of cardiovascular disease has not been significantly decreased, efforts have been made to understand the link between heart disease and novel therapeutic targets such as non-coding RNAs. Among multiple non-coding RNAs, long non-coding RNA (lncRNA) has emerged as a novel therapeutic in cardiovascular medicine. LncRNAs are endogenous RNAs that contain over 200 nucleotides and regulate gene expression. Recent studies suggest critical roles of lncRNAs in modulating the initiation and progression of cardiovascular diseases. For example, aberrant lncRNA expression has been associated with the pathogenesis of ischemic heart failure. In this article, we present a synopsis of recent discoveries that link the roles and molecular interactions of lncRNAs to cardiovascular diseases. Moreover, we describe the prevalence of circulating lncRNAs and assess their potential utilities as biomarkers for diagnosis and prognosis of heart disease.
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