[Thromboangiitis obliterans (Buerger's disease): update 2015]
Peter Klein-Weigel1, Theresa Sophie Volz1, Jutta Richter2
1Klinik für Angiologie, HELIOS Klinikum Berlin-Buch, Berlin.
Abstract:
Thromboangiitis obliterans (Buerger's disease) is a vasculitis with undulating clinical course multisegmentarily affecting small and medium-sized arteries and veins. The disease is closely linked to tobacco-use. Increasing knowledge of autoimmunologic mechanisms in the complex pathophyiology of the disease let to the formulation of an autoimmunity-hypothesis now serving as a new paradigma. New treatment options comprise progenitor-cell-therapy, immunoadsorption, use of sendothelin-receptor-blocking agent Bosentan, and prescriptions of antiphosphodiesterase-V-inhibitors.
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