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Updated: Apr 1, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
[The hepatorenal syndrome]
Uwe Heemann1, Hermann S Füeßl2, Lutz Renders1
1Abteilung für Nephrologie, Klinikum rechts der Isar, München.
Abstract:
The hepatorenal syndrome is characterized by a combination of liver cirrhosis, ascites and renal impairment. It is divided into two typs, whereby typ I is defined as acute with a doubling of creatinine within 2 weeks and type II as a more modest decline of kidney function. The only definite therapy so far is transplantation. However, based on pathophysiological considerations a number of strategies have been applied. Aldosteronantagonists are the backbone of therapy even in cases of poor diuresis. Additional benefit is derived from a combination of vasopressors and albumine.
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