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Glycemic control and arterial stiffness in a Brazilian rural population: Baependi Heart Study

Rafael de Oliveira Alvim1, Carlos Alberto Mourao-Junior2, Camila Maciel de Oliveira2

  • 1Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 44 Cerqueira César, São Paulo, SP CEP 05403-000 Brazil.

Diabetology & Metabolic Syndrome
|October 8, 2015
PubMed

Insights

Elevated hemoglobin A1c (HbA1c) levels are linked to increased arterial stiffness, particularly in older adults. This association is stronger in non-diabetic individuals, highlighting HbA1c as a key risk indicator.

Area of Science:

  • Cardiovascular Health
  • Endocrinology
  • Public Health

Background:

  • Arterial stiffness is a predictor of cardiovascular morbidity and mortality.
  • Impaired glycemic control correlates with heightened vascular stiffness.
  • The study investigated the link between HbA1c and arterial stiffness in a Brazilian rural population.

Purpose of the Study:

  • To assess the association between glycated hemoglobin (HbA1c) levels and increased arterial stiffness.
  • To explore this relationship within a Brazilian rural demographic.

Main Methods:

  • A cohort of 1675 adults (≥18 years) from Baependi, Brazil, was analyzed.
  • HbA1c levels were measured using High-Performance Liquid Chromatography (HPLC).
  • Arterial stiffness was quantified by measuring pulse wave velocity (PWV) using a non-invasive device.

Main Results:

  • HbA1c levels showed a significant association with increased PWV, especially in older age groups.
  • A one-unit increase in HbA1c correlated with a 54% rise in the odds of arterial stiffness (OR 1.54).
  • HbA1c and fasting glucose demonstrated greater predictive power for arterial stiffness in non-diabetics compared to diabetics.

Conclusions:

  • Increased HbA1c levels are associated with heightened arterial stiffness.
  • Both HbA1c and fasting glucose are more effective in assessing arterial stiffness risk in non-diabetic individuals.
Abstract

Keywords:
Arterial stiffnessGlycemic controlHbA1c

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