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Self-Report Tests of Personality01:22

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The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Diagnostic accuracy for major depression in multiple sclerosis using self-report questionnaires.

Anja Fischer1, Marcus Fischer2, Robert A Nicholls3

  • 1Department of Health Psychology, King's College London SE1 9RT, London, UK ; Center for Molecular Neurobiology, Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf Hamburg, Germany.

Brain and Behavior
|October 8, 2015
PubMed
Summary
This summary is machine-generated.

The Beck Depression Inventory (BDI) and Inventory of Depressive Symptomatology Self-Rated (IDS-SR30) accurately identify major depressive disorder in multiple sclerosis (MS) patients. The IDS-SR30 cognitive subscale is particularly useful for screening and assessing depressive symptoms.

Keywords:
Major depressive disordermultiple sclerosisself reportsensitivity and specificityvalidation studies

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Major depressive disorder (MDD) frequently co-occurs with multiple sclerosis (MS), yet depression is often undiagnosed in this population.
  • Self-rated depression questionnaires offer a viable alternative for diagnosis when standardized clinical assessments are not feasible.
  • Limited data exists on the diagnostic accuracy of self-report measures for depression specifically within the MS population, with a lack of head-to-head comparisons.

Purpose of the Study:

  • To compare the diagnostic accuracy of the Beck Depression Inventory (BDI) and the 30-item version of the Inventory of Depressive Symptomatology Self-Rated (IDS-SR30) for major depressive disorder (MDD) in multiple sclerosis (MS) patients.
  • To evaluate the utility of these self-report measures against a structured clinical interview diagnosis.
  • To assess the performance of different subscales of the questionnaires.

Main Methods:

  • A cohort of 31 MS patients reporting depressive symptoms completed the BDI and IDS-SR30.
  • Diagnostic assessment for MDD was performed using the Mini International Neuropsychiatric Interview (M.I.N.I.).
  • Receiver-Operating Characteristic (ROC) analyses were conducted to determine diagnostic accuracy, including error estimates and false-positive/negative rates.

Main Results:

  • A significant correlation was found between BDI and IDS-SR30 total scores (r = 0.82).
  • The IDS-SR30 total score, its cognitive subscore, and the BDI demonstrated excellent to good diagnostic accuracy, with Area Under the Curve (AUC) values of 0.86, 0.91, and 0.85, respectively.
  • These findings indicate strong performance of both instruments in identifying depression.

Conclusions:

  • Both the IDS-SR30 and BDI are valuable tools for quantifying depressive symptoms in MS patients, exhibiting good sensitivity and specificity.
  • The IDS-SR30 cognitive subscale shows particular promise as a screening tool for affective and cognitive depressive symptoms in this population.
  • These self-report measures can aid in the identification and management of depression in individuals with MS.