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Ghrelin, food intake, and botanical extracts: A Review
Peyman Rezaie1, Mohsen Mazidi2, Mohsen Nematy1
1Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna Journal of Phytomedicine
|October 8, 2015
Summary
Ghrelin, a growth hormone secretagogue, stimulates appetite and influences energy balance. This review explores ghrelin
Area of Science:
- Endocrinology
- Gastroenterology
- Nutritional Science
Background:
- Ghrelin, a growth hormone secretagogue (GHS), is primarily produced in the stomach.
- It activates the growth hormone secretagogue receptor 1a (GHS-R1a), influencing growth hormone release.
- Ghrelin plays a key role in appetite regulation and energy homeostasis.
Purpose of the Study:
- To review the multifaceted functions of ghrelin.
- To explore the impact of natural and medicinal plants on ghrelin levels and related physiological processes.
- To understand new aspects of ghrelin's role in nutritional and medical sciences.
Main Methods:
- Literature review of studies on ghrelin.
- Analysis of research investigating the effects of botanical extracts on appetite and hormone levels.
- Synthesis of current knowledge on ghrelin's physiological functions.
Main Results:
- Ghrelin is a primary meal initiator with appetite-stimulating effects.
- It contributes to long-term energy balance and nutritional status.
- Various plant-based interventions show potential in modulating appetite and ghrelin.
Conclusions:
- Ghrelin is a crucial hormone with significant implications for metabolism and appetite.
- Further research into plant-based modulators of ghrelin is warranted.
- Understanding ghrelin's functions is vital for nutritional and medical applications.
