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Updated: Apr 1, 2026
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
Published on: December 24, 2013
Tabernaemontana divaricata leaves extract exacerbate burying behavior in mice
Raj Chanchal1, Arumugam Balasubramaniam1, Raj Navin1
1Technocrats Institute of Technology Pharmacy, Anand Nagar, Bhopal- 462 021 (M.P.), India.
Objective:
Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice.
Materials And Methods:
Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus.
Results:
TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity.
Conclusion:
The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior.
