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Erythema migrans: a chronicle.

G J Dammin1

  • 1Department of Pathology, Harvard Medical School, Boston, Massachusetts.

Reviews of Infectious Diseases
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Erythema migrans (EM), initially described by Arvid Afzelius, can lead to disabling neurologic and arthritic sequelae. Lyme disease, caused by Borrelia burgdorferi and transmitted by Ixodes ticks, shares similarities with EM but presents with complex systemic manifestations.

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Area of Science:

  • Medical Entomology
  • Infectious Diseases
  • Dermatology

Background:

  • Erythema migrans (EM) was first described by Arvid Afzelius, who suspected a tick vector (Ixodes reduvius).
  • Neurologic and cutaneous syndromes linked to EM were recognized in Europe in the early 20th century.
  • Penicillin demonstrated effectiveness for treating EM in the mid-20th century.

Discussion:

  • Lyme disease, identified in 1975 in Connecticut, shares cutaneous features with EM but involves cardiac, neurologic, and arthritic sequelae.
  • The North American tick vector, Ixodes dammini, was identified in 1979, harboring agents for Lyme disease and babesiosis.
  • The causative spirochete was named Borrelia burgdorferi.

Key Insights:

  • Historical progression from EM description to Lyme disease recognition.

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  • Identification of the tick vector and causative agent (Borrelia burgdorferi).
  • Distinction and relationship between EM and Lyme disease clinical presentations.

    • Outlook:

    • Further research into North American and European Borrelia species.
    • Understanding the diverse clinical syndromes associated with Borrelia burgdorferi.
    • Continued investigation into tick-borne diseases and their sequelae.