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Published on: October 17, 2016
Bioresorbable scaffolds in daily clinical routine: a practical review of all-comers results
Jens Wiebe1, Christian W Hamm, Holger M Nef
1aUniversity of Giessen, Medizinische Klinik I, Department of Cardiology, Giessen bDeutsches Herzzentrum München, Munich cKerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany.
Purpose Of Review:
Bioresorbable scaffolds (BRS) are a major advancement in interventional cardiology, but experience with BRS use in daily routine is currently limited. Here, we review technical features of commercially available BRS and place them in context with current clinical scientific evidence.
Recent Findings:
Everolimus and novolimus-eluting poly-L-lactic acid (PLLA)-based BRS are commercially available in Europe. The everolimus-eluting BRS is the most widely investigated BRS and several all-comers investigations with this device are ongoing. Of the patients in these studies, 37-100% underwent catheterization due to acute coronary syndrome and up to 25% were diabetic. Up to 64.7% of all lesions treated were considered to be complex. Follow-up varied between 30 days and 1 year. The target lesion revascularization rate was up to 10% and scaffold thrombosis was 0-3%.
Summary:
Accumulating data on BRS application are now available. Several studies have demonstrated that BRS implantation is technically feasible in a variety of different patient subsets and clinical presentations, and follow-up results support BRS use. Patients with acute coronary syndrome represent the most investigated subpopulation, and results suggest that BRS use for this indication is reasonable.
