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Published on: August 8, 2025
Major femoral vascular access complications after coronary diagnostic and interventional procedures: A Danish
Ditte Dencker1, Frants Pedersen2, Thomas Engstrøm2
1Department of Radiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Insights
Vascular complications from femoral access during coronary angiography are rare (0.54%). Key risk factors include left-sided access, peripheral arterial disease, and female sex, informing safer vascular management strategies.
Area of Science:
- Cardiology
- Vascular Surgery
- Interventional Cardiology
Background:
- Vascular access complications following coronary angiography (CAG) and percutaneous coronary intervention (PCI) increase patient morbidity, hospitalization duration, and healthcare costs.
- Identifying risk factors and enhancing vascular management safety are crucial for improving patient outcomes in cardiovascular procedures.
- Femoral access is a common route for CAG and PCI, necessitating a thorough understanding of its associated complications.
Purpose of the Study:
- To determine the incidence of major vascular complications associated with femoral access during CAG and PCI.
- To identify significant risk factors contributing to the occurrence of these vascular complications.
Main Methods:
- A retrospective analysis of 23,870 index trans-femoral procedures (CAG) performed over six years in two centers.
- Data prospectively collected and entered into a database, cross-matched with national vascular registry data.
- Collection of demographic, procedural, mortality data, and information on access complications requiring surgery within 30 days.
Main Results:
- A total of 130 (0.54%) access complications requiring surgery were identified, including pseudoaneurysms (0.28%), arterial occlusions (0.19%), and hematomas (0.06%).
- Significant risk factors for complications included left-sided femoral access (OR 4.11), peripheral arterial disease (PAD) (OR 2.42), and female sex (OR 2.22).
- Arterial dissections were identified in 0.02% of cases.
Conclusions:
- The overall incidence of vascular complications related to femoral access in coronary diagnostic and interventional procedures is low at 0.54%.
- Left-sided femoral access, presence of peripheral arterial disease (PAD), and female sex are identified as significant risk factors for these complications.
- Findings underscore the importance of considering these risk factors for optimized vascular management and patient safety.
Background:
Vascular access complications after coronary angiography (CAG) and percutaneous coronary intervention (PCI) are known to increase morbidity, prolong hospitalization and raise hospital costs. Therefore, risk factor identification and improvement of safety strategies for vascular management are important. We aimed to assess the incidence of major vascular complications related to femoral access, and to identify potential risk factors.
Methods:
Over a period of six years, 23,870 index procedures (CAG) were performed in two centres, prospectively entered in the database and retrospectively analysed. Data was obtained from the Eastern Danish Heart Registry and cross-matched with data from the Danish Vascular Registry. Index procedures were defined as the first trans-femoral procedure. Demographic, procedural and mortality data, as well as information on access complications requiring surgery within 30 days were collected. Mortality data were collected for minimum 12 months.
Results:
We identified 130 (0.54%) access complications requiring surgery; 65 pseudoaneurysms (0.28%), 46 arterial occlusions (0.19%), 15 hematomas (nine groin and six retroperitoneal hematomas) (0.06%), and 4 arterial dissections (0.02%). Risk factors for complications were left sided femoral access (OR 4.11 [2.29-7.37] p<0.001), peripheral arterial disease (PAD) (OR 2.42 [1.48-3.94] p<0.0001) and female sex (OR 2.22 [1.51-3.24] p<0.0001).
Conclusion:
Vascular complications related to femoral access in coronary diagnostic and interventional procedures are low (0.54%). Risk factors were left sided access, PAD, and female sex.
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