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CRHBP polymorphisms predict chronic pain development following motor vehicle collision

Sarah D Linnstaedt1, Andrey V Bortsov, April C Soward

  • 1TRYUMPH Research Program, University of North Carolina, Chapel Hill, NC, USA Anesthesiology, University of North Carolina, Chapel Hill, NC, USA Emergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA Emergency Medicine, Spectrum Health System, Grand Rapids, MI, USA Emergency Medicine, Baystate Medical Center, Springfield, MA, USA Emergency Medicine, North Shore University Hospital, Manhasset, NY, USA Emergency Medicine, Saint Joseph Mercy Health System, Ypsilanti, MI, USA Emergency Medicine, University of Florida College of Medicine, Jacksonville, FL, USA Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA.

Pain
|October 9, 2015
PubMed
Summary

Genetic variants in stress-related genes, including corticotropin-releasing hormone-binding protein (CRHBP), predict chronic musculoskeletal pain (MSP) after motor vehicle collisions (MVC). These genes interact, influencing long-term pain severity following trauma.

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