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Thermoseparating aqueous two-phase systems: Recent trends and mechanisms
Yoong Kit Leong1, John Chi-Wei Lan2, Hwei-San Loh3
1Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih, Selangor Darul Ehsan, Malaysia.
Journal of Separation Science
|October 9, 2015
Summary
Temperature-induced aqueous two-phase systems (ATPSs) offer an eco-friendly and scalable method for bioproduct separation. These systems overcome limitations of conventional ATPSs, enabling efficient industrial bioextraction and purification.
Area of Science:
- Biotechnology
- Separation Science
- Green Chemistry
Background:
- Aqueous two-phase systems (ATPSs) are widely used for bioseparation due to their environmental friendliness, mild conditions, and scalability.
- Conventional ATPSs face limitations that hinder their industrial application.
- Temperature-induced ATPSs have emerged as a promising alternative with unique thermoseparating properties and enhanced recyclability.
Purpose of the Study:
- To provide a comprehensive review of temperature-induced aqueous two-phase systems (ATPSs).
- To discuss the history, characteristics, advantages, and influencing factors of thermoseparating ATPSs.
- To summarize recent applications and the underlying mechanisms of temperature-induced ATPSs.
Main Methods:
- Literature review of thermoseparating ATPSs.
- Analysis of the mechanism behind temperature-induced phase separation.
- Compilation of recent industrial and research applications.
Main Results:
- Temperature-induced ATPSs exhibit distinct thermoseparating properties and are easily recyclable.
- Key factors influencing partitioning in these systems have been identified.
- Recent applications demonstrate their effectiveness in bioextraction and purification.
Conclusions:
- Thermoseparating ATPSs offer an economically favorable and environmentally friendly solution for industrial-scale bioextraction and purification.
- These systems address the limitations of conventional ATPSs, paving the way for more sustainable bioprocessing.
- The review highlights the significant potential of temperature-induced ATPSs in the field of bioseparation.
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