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Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
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Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion.

Martin H Floch1, W Allan Walker, Mary Ellen Sanders

  • 1*Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT †Harvard Medical School ‡Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston ††Department of Transplantation, Lahey Hospital and Medical Center, Burlington, MA §Dairy & Food Culture Technologies, International Scientific Association of Probiotics and Prebiotics (ISAPP), Sacramento **Department of Medicine, University of California, San Diego, San Diego, CA ∥Departments of Internal Medicine, Academic Medical Center and VUmC, Amsterdam, The Netherlands ¶Wallenberg Laboratory, Gothenborg University, Gothenburg, Sweden #Minnesota Gastroenterology P.A., Minnesota, MN ‡‡Pediatric Liver & Liver Transplant, Gastroenterology/Transplantation, Phoenix Children's Hospital ∥∥Mayo Clinic, Phoenix §§Department of Pediatrics, University of Arizona, Tucson, AZ ¶¶Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Naples ##Clinical Hepato-Gastroenterology Unit, Division of Gastroenterology & Digestive Endoscopy, S. Raffaele University Hospital, Milano, Italy ***Division of Gastroenterology, University of Alberta, Edmonton, AB, Canada †††Department of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, NC ‡‡‡The Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital, Houston, TX §§§Department of Medicine, Weill Cornell Medical College, New York ∥∥∥Department of Medicine and Surgery, Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Journal of Clinical Gastroenterology
|October 9, 2015
PubMed
Summary
This summary is machine-generated.

This consensus report updates probiotic use guidelines for conditions like necrotizing enterocolitis and liver disease. Recommendations are rated A, B, or C for clinical application.

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Area of Science:

  • Gastroenterology and Hepatology
  • Microbiology

Background:

  • The 4th Triennial Yale/Harvard Workshop convened experts to establish consensus-based probiotic recommendations.
  • This update builds upon previous guidelines published in 2006, 2008, and 2011.
  • The scope now includes recommendations for liver disease, alongside established areas.

Framework:

  • Recommendations are categorized using an A, B, or C rating system.
  • This framework facilitates clinical decision-making regarding probiotic interventions.
  • The ratings reflect the strength of evidence and expert consensus.

Implementation:

  • Guidance is provided for the use of probiotics in pediatric and adult conditions.
  • Specific conditions covered include necrotizing enterocolitis, childhood diarrhea, inflammatory bowel disease, irritable bowel syndrome, and Clostridium difficile diarrhea.
  • New recommendations address the application of probiotics in liver disease management.

Implications:

  • These updated recommendations aim to standardize and optimize the clinical use of probiotics.
  • The inclusion of liver disease broadens the applicability of probiotic guidelines.
  • This consensus serves as a vital resource for healthcare professionals managing gastrointestinal and liver disorders.