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Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Collagens are the Major Structural Proteins of ECM01:13

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Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
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Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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Structural Protein Function01:56

Structural Protein Function

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
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Related Experiment Video

Updated: Apr 1, 2026

An Improved Method for the Preparation of Type I Collagen From Skin
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An Improved Method for the Preparation of Type I Collagen From Skin

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Biomedical applications of collagens.

John A M Ramshaw1

  • 1CSIRO Manufacturing, Parkville, Victoria, 3052, Australia.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|October 9, 2015
PubMed
Summary

Bacterial collagens offer a novel, disease-free source for advanced biomaterials. These adaptable materials can be engineered into various formats for diverse biomedical applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biotechnology

Background:

  • Collagen is a crucial component in numerous clinically accepted biomedical devices.
  • Current collagen biomaterials include stabilized tissues, purified collagens, and biosynthetic composites.
  • Advancements in understanding collagen structure and function drive material innovation.

Purpose of the Study:

  • To review the development and potential of novel collagen sources for biomaterials.
  • To highlight bacterial collagens as a promising alternative to animal-derived collagen.
  • To discuss the fabrication and functional modification of these new collagen materials.

Main Methods:

  • Review of recent literature on collagen biomaterials.
  • Discussion of the characteristics of bacterial collagens.
Keywords:
biomolecular engineeringcell therapycollagenmicrospheresvascular prosthesis

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  • Exploration of fabrication techniques for collagen-based devices.

    • Main Results:

    • Recombinant collagen materials offer well-defined, disease-free options.
    • Bacterial collagens present a novel, non-animal source for biomaterials.
    • These bacterial collagens can be modified and fabricated into films, sponges, and surface coatings.

    Conclusions:

    • Bacterial collagens represent a significant advancement in biomaterial development.
    • The adaptability and fabrication potential of bacterial collagens open new avenues for biomedical applications.
    • Further research into bacterial collagens is warranted for optimizing their use in regenerative medicine and device engineering.