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Method to Obtain Pattern of Breathing in Senescent Mice through Unrestrained Barometric Plethysmography
Published on: April 28, 2020
Sleep Apnea Research in Animals. Past, Present, and Future
Swati Chopra1, Vsevolod Y Polotsky1, Jonathan C Jun1
1Division of Pulmonary and Critical Care Medicine Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Abstract:
Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of the upper airway during sleep. Animal models have been pivotal to the understanding of OSA pathogenesis, consequences, and treatment. In this review, we highlight the history of OSA research in animals and include the discovery of animals with spontaneous OSA, the induction of OSA in animals, and the emulation of OSA using exposures to intermittent hypoxia and sleep fragmentation.

