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Plateletcrit in Ocular Pseudoexfoliation Syndrome
Serpil Yazgan1, Ugur Celik, Havva Kaldrm
1Department of Ophthalmology (S.Y., O.A., M.O.A.), Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey; Department of Ophthalmology (U.C.), Taksim Research and Education Hospital, Istanbul, Turkey; Department of Ophthalmology (H.K.), Bagcilar Research and Education State Hospital, Istanbul, Turkey.
Plateletcrit (PCT) and platelet distribution width (PDW) were higher in patients with ocular pseudoexfoliation (PEX) syndrome. These platelet markers may indicate increased cardiovascular risk and reduced aqueous humor outflow in PEX.
Area of Science:
- Ophthalmology
- Hematology
Background:
- Ocular pseudoexfoliation (PEX) syndrome is a condition affecting the eye.
- Platelet markers are crucial in various physiological and pathological processes.
Purpose of the Study:
- To compare plateletcrit (PCT) and other platelet markers in patients with and without ocular PEX syndrome.
Main Methods:
- A retrospective case-control study included 106 patients with ocular PEX syndrome and 106 controls.
- Platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and PCT were analyzed.
Main Results:
- Patients with PEX syndrome showed significantly higher PCT (P<0.001) and PDW (P<0.001) compared to controls.
- No significant differences were observed in MPV or PLT between the groups.
- A PCT cutoff of 0.180 demonstrated 65% sensitivity and 74% specificity for PEX syndrome.
Conclusions:
- Elevated PCT and PDW in ocular PEX syndrome suggest increased platelet activity.
- These findings may link PEX syndrome to microvascular resistance, inflammation, and potentially reduced aqueous humor outflow.
