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[Prevalence of Types TEM, SHV and CTX-M βLES Among Pathogens of Chronic Pyelonephritis]

A V Bilchenko, O I Chub

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |October 10, 2015
    PubMed

    Insights

    Uropathogens increasingly resist β-lactam antibiotics due to plasmid-induced β-lactamases. Identifying TEM, SHV, and CTX-M types is crucial for effective antibiotic selection in urinary tract infections.

    Area of Science:

    • Microbiology
    • Molecular Biology
    • Clinical Medicine

    Context:

    • Rising antimicrobial resistance in uropathogens is a significant global health concern.
    • Plasmid-mediated β-lactamase production is a primary mechanism for resistance to β-lactam antibiotics.
    • Urinary tract infections (UTIs) are commonly caused by bacteria, with increasing resistance complicating treatment.

    Purpose:

    • To identify the prevalence and types of plasmid-encoded β-lactamases (TEM, SHV, CTX-M) in uropathogenic bacteria.
    • To determine the antimicrobial resistance patterns associated with these β-lactamase-producing strains.
    • To assess the susceptibility of these resistant uropathogens to various antibiotic classes.

    Summary:

    • 30% of 115 uropathogen isolates produced β-lactamases, with blaTEM and blaCTX-M genes being most common.
    • Resistant strains showed high resistance to ampicillin, ciprofloxacin, levofloxacin, and gentamicin.
    • β-lactamase-producing strains remained largely susceptible to meropenem, nitroxolin, phosphomycin, and amikacin.

    Impact:

    • The study highlights the widespread distribution of plasmid-mediated resistance genes among uropathogens.
    • Detecting plasmid-induced β-lactamases is vital for guiding empirical antibiotic therapy choices.
    • Understanding resistance mechanisms aids in developing strategies to combat antimicrobial resistance in UTIs.

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