Related Experiment Video
Updated: Aug 9, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
Pulmonary toxicity of nitrofurantoin
1National Rehabilitation Hospital, Washington, DC 20010.
Abstract:
Nitrofurantoin is frequently used by the physiatrist for treatment of urinary tract infections or for urinary antimicrobial prophylaxis. There is a substantial risk of acute and chronic pulmonary side effects with this medication. The acute pulmonary toxicity presents with fever, leukocytosis, dyspnea, and nonproductive cough. Chronic nitrofurantoin use can lead to interstitial pulmonary fibrosis. A case is reported of a 47-year-old spinal cord injured woman with an acute pulmonary reaction to nitrofurantoin. The literature pertaining to pulmonary toxicity of nitrofurantoin is reviewed.
More Related Videos
07:38A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
Published on: April 13, 2018
06:03Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
Published on: May 9, 2025
Related Concept Videos
2° Amines to N-Nitrosamines: Reaction with NaNO2
Physical Properties of Amines
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Drug Toxicity: Dose-Dependent Reactions
Drug toxicity: Drug–Drug Interaction