Related Experiment Video
Updated: Apr 1, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Statin effects on atherosclerotic plaques: regression or healing?
Marcio Sommer Bittencourt1,2, Rodrigo Julio Cerci3
1Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute; University of São Paulo School of Medicine, Av. Lineu Prestes, 2565, São Paulo, 05508-000, Brazil. mbittencourt@hu.usp.br.
Abstract:
Despite the well-documented improved survival of coronary heart disease with the use of statins, their effects on atherosclerotic plaques are not yet fully understood. While some studies suggest statins may reduce plaque volume, the reduction is small even with the use of high-dose statins. Due to this small change in plaque volume, other effects of statin therapy on plaques have been proposed. A large meta-analysis by Banach et al. explored statin effects on plaque composition detected by intravascular ultrasound (IVUS). We discuss the mechanisms of plaque composition modification demonstrated in their study and its implications on atherosclerotic plaque stabilization. Please see related article: http://www.biomedcentral.com/1741-7015/13/229.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Atherosclerosis III: Management
Atherosclerosis I: Introduction
Inflammation
Atherosclerosis IV: Nursing Management
Peripheral Artery Disease III: Interprofessional Care

