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Updated: Apr 1, 2026
10:14
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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Renal extramedullary hematopoiesis: interstitial and glomerular pathology
Mariam P Alexander1, Samih H Nasr1, Paul J Kurtin2
1Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Summary
Renal extramedullary hematopoiesis, a rare condition, often presents with renal insufficiency and proteinuria. It is frequently associated with underlying hematologic malignancies and can be misdiagnosed.
Area of Science:
- Nephrology
- Hematology
- Pathology
Background:
- Renal extramedullary hematopoiesis (REM) is infrequently diagnosed before autopsy.
- Patients with REM often present with renal insufficiency and proteinuria.
Purpose of the Study:
- To describe the clinicopathologic features of REM in antemortem specimens.
- To highlight the association between REM, glomerular diseases, and hematologic malignancies.
Main Methods:
- Retrospective review of 14 patients with REM diagnosed antemortem between 1994 and 2015.
- Histopathological analysis of renal biopsies and clinical data review.
Main Results:
- All 14 patients had underlying hematologic malignancies, most commonly primary myelofibrosis.
- Patients presented with renal insufficiency (mean creatinine 2.9 mg/dL) and proteinuria (mean 7.9 g/24h).
- Concurrent glomerular diseases were common, and REM was sometimes misdiagnosed as interstitial nephritis.
Conclusions:
- REM should be considered in the differential diagnosis of interstitial infiltrates, especially with glomerulopathy and hematologic malignancy.
- Early recognition and diagnosis are crucial for appropriate management, although prognosis is often poor due to the underlying malignancy.
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