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Super-Period Gold Nanodisc Grating-Enabled Surface Plasmon Resonance Spectrometer Sensor
Xueli Tian1, Hong Guo, Ketan H Bhatt
1Department of Electrical and Computer Engineering, University of Alabama in Huntsville, 301 Sparkman Dr., Huntsville, Alabama 35899 USA.
Applied Spectroscopy
|October 10, 2015
Summary
This study introduces a novel surface plasmon resonance (SPR) sensor using a gold nanodisc grating. This SPR sensor effectively detects protein nanolayers, offering a new tool for biosensing applications.
Area of Science:
- Nanophotonics and Plasmonics
- Optical Spectroscopy
- Biosensing Technology
Background:
- Surface plasmon resonance (SPR) is a label-free optical technique widely used for detecting molecular interactions.
- Traditional SPR sensors often rely on prism-based configurations or simple gratings, which can limit sensitivity and spectral resolution.
- Developing advanced nanostructured surfaces is crucial for enhancing SPR performance and enabling new sensing modalities.
Purpose of the Study:
- To experimentally demonstrate a novel SPR spectrometer sensor.
- To utilize an e-beam-patterned super-period gold nanodisc grating for enhanced SPR detection.
- To showcase the sensor's capability in detecting protein nanolayer bonding.
Main Methods:
- Fabrication of a super-period gold nanodisc grating on a glass substrate using electron-beam lithography.
- Exploiting the small subwavelength period for enhanced localized surface plasmon resonance (LSPR).
- Utilizing the large diffraction grating period to spectrally resolve SPR radiation in different diffraction orders.
- Measuring SPR spectra via first-order diffraction profiles captured by a charge-coupled device (CCD) and zeroth-order transmission.
Main Results:
- The super-period grating successfully enhanced LSPR.
- SPR spectra were effectively measured in the first-order diffraction using a CCD, complementing traditional zeroth-order measurements.
- A significant SPR shift was observed, demonstrating the sensor's ability to detect bovine serum albumin (BSA) protein nanolayer bonding.
- The sensor achieved label-free detection of protein adsorption.
Conclusions:
- The demonstrated SPR sensor based on a super-period gold nanodisc grating offers a sensitive and spectrally resolved detection method.
- This nanostructured SPR sensor provides an alternative to conventional SPR setups, with potential for improved performance.
- The sensor's successful application in detecting protein nanolayers highlights its promise for various biosensing applications.
