Related Experiment Video
Updated: Apr 1, 2026
03:37
Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
5.3K
Elevated risperidone serum concentrations during acute inflammation, two cases.
Gudrun Hefner1, Tanja Falter2, Kai Bruns2
1Department of Psychiatry and Psychotherapy, University Medical Center, Mainz, Germany Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center, Mainz, Germany gudrun.hefner@unimedizin-mainz.de.
International Journal of Psychiatry in Medicine
|October 10, 2015
Summary
Acute inflammation can significantly increase risperidone levels in patients with schizophrenia, potentially leading to toxicity. Monitoring C-reactive protein is crucial for adjusting risperidone dosage during inflammatory episodes.
Area of Science:
- Pharmacology
- Psychiatry
- Clinical Medicine
Background:
- Psychotropic drug metabolism can be altered by inflammation, affecting drug levels and potentially causing toxicity.
- Risperidone is a key antipsychotic medication used for schizophrenia and related disorders.
Observation:
- Two patients with schizophrenia experienced a threefold increase in risperidone's active moiety serum concentrations during acute inflammation.
- Serum concentrations of risperidone and C-reactive protein showed parallel fluctuations over time in both patients.
Findings:
- Elevated C-reactive protein, an indicator of inflammation, correlated with increased risperidone levels.
- The observed increases in drug levels were not attributable to prescribed comedications, suggesting inflammation as the cause.
Implications:
- Elevated C-reactive protein should prompt monitoring of risperidone blood levels in patients.
- Consideration of dose adjustment for risperidone may be necessary during inflammatory conditions to prevent toxicity.
Related Concept Videos
01:24Mania and Antimanic Drugs: Overview
774
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
774
01:26Psychosis: Goals of Pharmacotherapy
663
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
663
01:23Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
878
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
878
01:29Therapeutic Drug Monitoring: Affecting Factors
333
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
333
01:28Psychosis and Antipsychotic Drugs: Overview
1.2K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.2K
01:24Drug Toxicity: Risk factors
171
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
171