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Topical treatment of basal cell carcinoma with the immune response modifier imiquimod

Dimitrios Papakostas1, Eggert Stockfleth2

  • 1Department of Dermatology & Venerology, A Syggros Hospital, University of Athens, Medical School, 5, I. Dragoumi Str. 16121 Athens, Greece.

Future Oncology (London, England)
|October 10, 2015
PubMed

Imiquimod, a TLR7 agonist, is a novel immune response modifier currently widely used in the treatment of actinic keratoses (in situ squamous cell carcinoma). Imiquimod has revolutionized the treatment of field cancerization and has been approved for the treatment of superficial basal cell carcinoma with the recommendation of a 6-week treatment strategy, offering an alternative to surgery or other destructive treatment strategies.

Keywords:
5-FUBCC nevus syndromeHedgehog signaling cascadeMohs surgeryToll-like receptoractinic keratosisbasal cell carcinomacondylomata accuminatacytokinesfield cancerizationimiquimodimmunosuppressioninflammationinterferonnonmelanoma skin cancerorgan transplantationphotodynamic therapyradiationskin agingsun exposure

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