Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

7.8K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
7.8K
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

18.4K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
18.4K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
Abnormal Proliferation02:23

Abnormal Proliferation

3.8K
3.8K
Cancer02:18

Cancer

55.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.8K
What is Cancer?02:12

What is Cancer?

15.6K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
15.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

The bone & joint journal·2026
Same author

Complications of PI to PIII hemipelvic resections for intermediate and malignant tumours : a systematic review and meta-analysis.

Bone & joint open·2026
Same author

Outcome of type 4 pelvic resection and reconstruction with a high hip center in malignant pelvic tumours: A case series and short-term review.

Journal of orthopaedic surgery (Hong Kong)·2026
Same author

Surgical Management of Chondrosarcoma of the T11 With The Aid of a 3D Printed Model: A Case Report With Review of Literature.

Indian journal of orthopaedics·2026
Same author

Managing Extensive Pigmented Villonodular Synovitis with Wide Resection and Endoprosthesis Replacement at the Elbow and Ankle Joints: A Mid-term Outcome.

Indian journal of orthopaedics·2026
Same author

A modified Delphi consensus on periprosthetic infection in orthopaedic oncology : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

The bone & joint journal·2025

Related Experiment Video

Updated: Apr 1, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.8K

Granular cell tumour: malignant or benign?

Vivek Ajit Singh1, Jayaletchumi Gunasagaran1, Jayalakshmi Pailoor2

  • 1Orthopaedic Oncology Unit, Department of Orthopaedics, University of Malaya, Malaysia.

Singapore Medical Journal
|October 10, 2015
PubMed
Summary

Granular cell tumours (GrCTs) of the extremities are rare. Differentiating benign from malignant GrCTs is crucial for prognosis, with wide local excision recommended for both types.

Keywords:
benigngranular cell tumourmalignant

More Related Videos

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
10:58

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

13.6K
Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

18.7K

Related Experiment Videos

Last Updated: Apr 1, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.8K
Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
10:58

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

13.6K
Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

18.7K

Area of Science:

  • Orthopaedic Oncology
  • Soft Tissue Tumours
  • Pathology

Background:

  • Granular cell tumours (GrCTs) are uncommon soft tissue neoplasms.
  • Malignant GrCTs are rare but aggressive, necessitating accurate diagnosis for appropriate management.
  • Distinguishing between benign and malignant GrCTs is critical due to differing prognoses.

Purpose of the Study:

  • To review cases of GrCTs of the extremities.
  • To evaluate the diagnostic utility of the Fanburg-Smith criteria in differentiating GrCT subtypes.
  • To assess treatment outcomes for GrCTs of the extremities.

Main Methods:

  • Retrospective review of GrCT cases of the extremities.
  • Cases were treated at the Orthopaedic Oncology Unit, University Malaya Medical Centre.
  • Diagnosis and classification were based on histopathological examination using the Fanburg-Smith criteria.

Main Results:

  • Five cases of GrCTs of the extremities were identified, affecting five female patients aged 13-40.
  • Three cases were benign, one atypical, and one malignant GrCT.
  • Wide local excision was performed for all cases; outcomes were excellent for benign/atypical cases, but the malignant case developed lung metastasis.

Conclusions:

  • Clinical presentation and Fanburg-Smith criteria aid in differentiating benign from malignant GrCTs.
  • Wide local excision is the preferred treatment for both benign and malignant GrCTs.
  • Further research into adjuvant therapies for malignant GrCTs and long-term patient follow-up are recommended.