The Great Pretender: Rectal Syphilis Mimic a Cancer
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Updated: Oct 12, 2026

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
Published on: September 21, 2015
Andrea Pisani Ceretti1, Matteo Virdis1, Nirvana Maroni1
1Department of HBP & Digestive Surgery, University of Milan, San Paolo Hospital, Via A. Di Rudinì 8, 20142 Milan, Italy.
Abstract:
Rectal syphilis is a rare expression of the widely recognised sexual transmitted disease, also known as the great imitator for its peculiarity of being confused with mild anorectal diseases because of its vague symptoms or believed rectal malignancy, with the concrete risk of overtreatment. We present the case of a male patient with primary rectal syphilis, firstly diagnosed as rectal cancer; the medical, radiological, and endoscopic features are discussed below.
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