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Updated: Apr 1, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer
Pablo Argüeso1, Jerome Mauris1, Yuichi Uchino1
1Schepens Eye Research Institute and Massachusetts Eye and Ear; Department of Ophthalmology ; Harvard Medical School; Boston, MA USA.
Abstract:
Epithelial cells are closely connected to each other and to the extracellular matrix by a set of adhesive contacts that provide tissues with unique barrier properties and play a prominent role in cell morphology, tissue physiology, and cell signaling. This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function. The interactions of galectin-3 within adhesive structures are discussed in relation to wound healing and tumor progression.
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