Related Experiment Video

Updated: Apr 1, 2026

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
04:56

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm

Published on: August 1, 2025

647

Risk Stratification of Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm Using Aortic

Marianne Beckmann1, Vincenzo Jacomella2, Malcom Kohler3

  • 1Clinic for Angiology, University Hospital Zurich and University of Zurich, Zurich, Switzerland; Angiology Division, Department of Internal Medicine, Kantonsspital St. Gallen, St Gallen, Switzerland.

Plos One
|October 10, 2015
PubMed

Insights

Central augmentation index (cAIx) varies with vascular disease patterns. Obstructive peripheral arterial disease (PAD) shows higher cAIx than aneurysmatic disease, indicating differences in arterial stiffness.

Area of Science:

  • Cardiovascular research
  • Vascular medicine
  • Biomedical engineering

Background:

  • Central augmentation index (cAIx) is a key indicator of vascular stiffness.
  • Obstructive and aneurysmatic vascular diseases impact pulse wave dynamics and central aortic pressures.

Purpose of the Study:

  • To compare central augmentation index (cAIx) in patients with peripheral arterial disease (PAD) and/or abdominal aortic aneurysm (AAA).
  • To investigate how different vascular disease patterns affect arterial stiffness measurements.

Main Methods:

  • Central augmentation index (cAIx) was measured using radial applanation tonometry in 184 patients.
  • Patients were categorized into PAD only, AAA only, or combined AAA and PAD groups.
  • Statistical analyses included non-parametric tests and multivariate regression to assess associations with vascular disease patterns.

Main Results:

  • Mean cAIx was 30.5 ± 8.2%.
  • Significantly higher cAIx was observed in females and patients over 80 years.
  • cAIx was lowest in AAA patients (27.3 ± 9.5%), intermediate in AAA & PAD (28.8 ± 8.5%), and highest in PAD only (31.4 ± 7.8%).

Conclusions:

  • Non-invasive assessment of arterial stiffness reveals distinct cAIx patterns based on vascular disease type.
  • Obstructive PAD is associated with significantly higher cAIx compared to aneurysmatic disease.
Abstract

More Related Videos

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model09:32

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model

Published on: February 23, 2020

6.9K
Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation09:32

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Published on: September 19, 2018

16.6K

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
520
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
450
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
669
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
582
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
613
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
750