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Related Experiment Video

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Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
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Motion Sickness: Current Knowledge and Recent Advance.

Li-Li Zhang1, Jun-Qin Wang2, Rui-Rui Qi2

  • 1Department of Pharmacology, Second Military Medical University, Shanghai, China.

CNS Neuroscience & Therapeutics
|October 11, 2015
PubMed
Summary
This summary is machine-generated.

Motion sickness (MS) is a common response to motion, influenced by sensory conflict and neurobiological factors. This review covers its causes, prediction, evaluation, and effective countermeasures like training and behavioral changes.

Keywords:
CountermeasureEvaluationMotion sicknessPathogenesisPrediction

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Area of Science:

  • Neuroscience
  • Physiology
  • Human Factors

Background:

  • Motion sickness (MS) is a prevalent condition affecting individuals during real or virtual motion.
  • Understanding its neurobiological underpinnings and effective management strategies is crucial.

Purpose of the Study:

  • To provide a comprehensive review of the current knowledge on motion sickness.
  • To summarize its pathogenesis, pathophysiology, prediction, evaluation, and countermeasures.

Main Methods:

  • Review of existing literature on motion sickness.
  • Analysis of the sensory conflict hypothesis and neurobiological correlates.
  • Evaluation of diagnostic tools like questionnaires, heart rate variability (HRV), and electrogastrogram (EGG).

Main Results:

  • The sensory conflict hypothesis is the leading theory.
  • Hippocampus and vestibular cortex are implicated in internal model formation.
  • Visceral afference, thermoregulation, and neuroendocrine factors contribute to pathophysiology.
  • Genetic factors (SNPs) and epigenetics may influence susceptibility and habituation.
  • Questionnaires, HRV, and EGG are valuable diagnostic tools.
  • Medications, repeated real motion exposure, visual-vestibular training, behavioral, dietary, and physiotherapy interventions are effective countermeasures.

Conclusions:

  • Motion sickness involves complex neurobiological mechanisms and is influenced by genetic and epigenetic factors.
  • A multi-faceted approach combining diagnostic tools and various countermeasures is effective for managing motion sickness.