Related Experiment Video
Updated: Apr 1, 2026

Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction
Published on: July 25, 2025
Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children
Julie C Brown1, Rachel E Tuuri2, Sabreen Akhter1
1Seattle Children's Hospital and University of Washington, Seattle, WA.
Epinephrine autoinjector injuries in children, including lacerations, are occurring. Device design and instructions may contribute to these risks, necessitating improvements for safer use.
Area of Science:
- Pediatric Emergency Medicine
- Anaphylaxis Management
- Medical Device Safety
Background:
- Epinephrine autoinjectors are increasingly used for anaphylaxis treatment in children.
- Previous reports have documented digit injections but not lacerations from autoinjector misuse.
- This study investigates complications associated with pediatric epinephrine autoinjector use.
Purpose of the Study:
- To report and analyze complications of epinephrine autoinjector use in children.
- To discuss how device features and instructions may contribute to injuries.
- To identify potential improvements for reducing autoinjector-related harm.
Main Methods:
- A review of emergency medicine discussion lists and social media allergy groups was conducted.
- Cases of epinephrine autoinjector injuries involving children were identified and analyzed.
Main Results:
- Twenty-two cases of epinephrine autoinjector injuries in children were identified.
- Seventeen children sustained lacerations, and four experienced needle-stick injuries.
- Device design and lack of instructions for leg immobilization were noted as contributing factors.
Conclusions:
- Epinephrine autoinjectors are vital for anaphylaxis, but injuries can occur in children.
- Improving device design, minimizing injection time, and providing clear instructions are crucial.
- Recommendations include immobilizing the leg and enhancing needle retraction features.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Allergic Reactions
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Clinical Applications of Epidermal Stem Cells
Prevention of Further Absorption of Poison
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

