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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

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Adenosine-associated delivery systems.

Mehdi Kazemzadeh-Narbat^1,2,3, Nasim Annabi^1,2,4,5, Ali Tamayol^1,2

¹a Division of Biomedical Engineering, Department of Medicine , Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA .

Journal of Drug Targeting

|October 11, 2015

Summary

This summary is machine-generated.

Adenosine offers therapeutic potential but faces challenges due to side effects and a short half-life. This review explores advanced adenosine delivery systems to improve efficacy and reduce adverse events.

Keywords:

Adenosine controlled drug delivery controlled release drug delivery drug targeting nanoparticles targeted drug delivery

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Area of Science:

Biomedical Engineering
Pharmacology
Drug Delivery Systems

Background:

Adenosine is a vital nucleoside with therapeutic applications in arrhythmias, CNS disorders, and seizures.
Systemic administration of adenosine is limited by severe side effects and a very short biological half-life (<10 seconds).

Purpose of the Study:

To critically review various adenosine delivery techniques.
To highlight existing challenges in developing effective adenosine delivery systems.

Main Methods:

Review of current literature on adenosine delivery strategies.
Analysis of encapsulation, cell-based, biomaterial, and mechanical delivery systems.

Main Results:

Various advanced delivery systems show promise for sustained adenosine release.
Significant challenges remain in optimizing these systems for clinical translation.

Conclusions:

Novel adenosine delivery systems are crucial for enhancing therapeutic efficacy and minimizing side effects.
Further research is needed to overcome technical hurdles for widespread clinical adoption.