Cell Models to Study Cell-to-Cell Transmission of α-Synuclein
Eun-Jin Bae1, He-Jin Lee2,3, Seung-Jae Lee4
1Neuroscience Research Institute and Department of Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongro-gu, 110-799, South Korea.
Abstract:
The cell-to-cell transmission of protein aggregates has been implicated in the progression of pathological phenotypes in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. In recent years, several experimental model systems have been developed to study the mechanisms of cell-to-cell transmission. Herein, we describe cell culture models with which cell-to-cell transmission of α-synuclein can be quantitatively analyzed. The principle underlying these models could be applied to developing model systems for transmission of other protein aggregates, such as tau and TDP-43.
