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Neuronal control of bone and muscle
Peter Houweling1, Rishikesh N Kulkarni2, Paul A Baldock3
1Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, VIC, Australia.
Bone
|October 11, 2015
Summary
The sympathetic nervous system and neuronal inputs regulate bone and muscle physiology. This review explores their co-regulatory actions, offering new insights into the bone/muscle unit coordination.
Area of Science:
- Physiology
- Neuroscience
- Orthopedics
Background:
- Locomotion relies on bone-muscle interplay.
- Emerging research highlights broader regulatory connections between bone and muscle.
- Neuronal signaling is crucial for bone turnover and muscle contraction.
Purpose of the Study:
- To review the role of the sympathetic nervous system and neuronal/neuropeptide inputs in regulating bone and muscle.
- To explore potential co-regulatory actions between these systems.
- To provide new insights into the coordination of the bone/muscle unit.
Main Methods:
- Literature review of studies on neuronal regulation of bone and muscle.
- Analysis of sympathetic nervous system's role.
- Examination of neuropeptide signaling pathways.
Main Results:
- Neuronal inputs influence a wider range of bone and muscle physiology than previously understood.
- The sympathetic nervous system plays a significant role in regulating bone and muscle tissue.
- Co-regulatory actions between neuronal systems and bone/muscle are significant.
Conclusions:
- Neuronal signaling, particularly from the sympathetic nervous system, is a key regulator of bone and muscle.
- Understanding these interactions is crucial for comprehending the coordinated function of the bone/muscle unit.
- Further research into these neuro-musculoskeletal connections is warranted.
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