Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to the Skeletal System01:20

Introduction to the Skeletal System

8.4K
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
8.4K
The Muscular System01:18

The Muscular System

6.3K
The muscular system is essential to the body's overall structure and function, playing a crucial role in movement, stability, and internal processes. It consists of three distinct types of muscle tissue: the skeletal, the smooth, and the cardiac muscles.
6.3K
The Bone Matrix01:18

The Bone Matrix

5.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.3K
Introduction to Joints00:58

Introduction to Joints

4.5K
The adult human body usually has 206 bones, and except for the hyoid bone in the neck, each bone is connected to at least one other bone. Joints are the location where bones come together. Many joints allow for movement between the bones. At these joints, the articulating surfaces of the adjacent bones can move smoothly against each other. However, the bones of other joints may be joined by connective tissue or cartilage. These joints are designed for stability and provide little or no...
4.5K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.5K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.5K
Spongy Bone01:09

Spongy Bone

7.2K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benzothiazole Derivatives as Dual Modulators of PGE2 and GABAergic Signaling in Skeletal Muscle.

bioRxiv : the preprint server for biology·2026
Same author

Innovations in skeletal muscle regeneration: from physiology to bioengineering approaches for repair and restoration.

Frontiers in physiology·2026
Same author

Expanding the Autosomal Recessive Hypophosphatemic Rickets Type I Carrier Phenotype and Adult Treatment with Burosumab.

Calcified tissue international·2026
Same author

Absence of Neuromuscular Dysfunction in Mice with Gut Epithelium-Restricted Expression of ALS Mutation hSOD1<sup>G93A</sup>.

Biomolecules·2026
Same author

Meeting report: the inaugural muscle biology and cachexia conference at the University of Houston, May 18-20, 2025, Houston, Texas, USA.

Frontiers in physiology·2025
Same author

Separation and Quantification of Isomeric Forms of Aminobutyric Acids.

Methods in molecular biology (Clifton, N.J.)·2025

Related Experiment Videos

Bone and muscle: Interactions beyond mechanical.

Marco Brotto1, Lynda Bonewald2

  • 1Muscle Biology Research Group-MUBIG, UMKC School of Nursing & Health Studies, 2464 Charlotte, USA; UMKC School of Medicine, 2464 Charlotte, USA.

Bone
|October 11, 2015
PubMed
Summary
This summary is machine-generated.

Musculoskeletal system research traditionally focused on mechanical interactions. This review highlights the crucial, yet under-recognized, molecular and biochemical communication between bone and muscle for understanding development and disease.

Keywords:
BoneBone–muscle crosstalkGene pleiotropyMuscleSecreted factors

Related Experiment Videos

Area of Science:

  • Biomedical Science
  • Skeletal Biology
  • Connective Tissue Research

Background:

  • Traditional musculoskeletal research often employs reductionist approaches, studying components like bone and muscle separately.
  • Mechanical interactions are key to locomotion and musculoskeletal development, dominating current understanding.
  • Molecular and biochemical interactions between musculoskeletal tissues remain less explored.

Purpose of the Study:

  • To review the dominance of mechanical coupling theories in bone-muscle interaction research.
  • To present evidence for the secretory nature of bone and muscle.
  • To explore genetic and biochemical communication pathways between bone and muscle.

Main Methods:

  • Literature review of existing research on musculoskeletal interactions.
  • Analysis of evidence supporting mechanical and biochemical communication theories.
  • Identification of physiological questions not addressed by mechanical theories alone.

Main Results:

  • Mechanical coupling theories have historically dominated bone-muscle interaction research due to ease of measurement.
  • Evidence suggests both bone and muscle possess secretory functions.
  • Genetic and biochemical signaling pathways between bone and muscle are increasingly recognized.

Conclusions:

  • A paradigm shift is needed to incorporate biochemical and molecular signaling into musculoskeletal research.
  • Understanding these interactions is vital for basic science and developing therapies for co-existing bone and muscle diseases.
  • Further research into cellular and molecular mechanisms of bone-muscle communication is warranted.