Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunotherapy in asthma.

P S Creticos1

  • 1Division of Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21239.

The Journal of Allergy and Clinical Immunology
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

Investigating allergic rhinitis using a nasal challenge model reveals how mediator release impacts respiratory symptoms. Immunotherapy can reduce mediator release and symptom severity, helping to manage allergic reactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical trials in allergen immunotherapy in the age group of children and adolescents: current concepts and future needs.

Clinical and translational allergy·2020
Same author

Magnitude of efficacy measurements in grass allergy immunotherapy trials is highly dependent on pollen exposure.

Allergy·2014
Same author

Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes T(H)1 cytokine expression while downregulating T(H)2 cytokine expression in PBMCs from human patients with ragweed allergy.

The Journal of allergy and clinical immunology·2001
Same author

The consideration of immunotherapy in the treatment of allergic asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001
Same author

Managing asthma in adults.

The American journal of managed care·2001
Same author

Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity.

The Journal of allergy and clinical immunology·2000

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Allergy Research

Background:

  • Allergic asthma and allergic rhinitis are inflammatory respiratory conditions.
  • Understanding mediator release in the upper airway can inform lower airway responses.
  • Allergen load and priming significantly influence nasal and bronchial reactivity.

Purpose of the Study:

  • To elucidate mediator release in the allergic diathesis using a nasal challenge model.
  • To examine the relationship between mast cell activation and early-phase allergic symptoms.
  • To assess the role of immunotherapy in modulating allergic responses.

Main Methods:

  • Utilized a nasal challenge model to study allergic respiratory responses.
  • Monitored mast cell activation and mediator release.

Related Experiment Videos

  • Assessed the impact of immunotherapy on IgG titers and clinical response.

    • Main Results:

    • Mast cell activation and mediator release correlated with early-phase allergic symptoms.
    • Immunotherapy led to increased IgG titers.
    • The model demonstrated the balance between protective IgG and allergic IgE responses.

    Conclusions:

    • Nasal challenge models are valuable for studying allergic respiratory inflammation.
    • Immunotherapy may mitigate allergic reactions by reducing mediator release and symptom severity.
    • A combination of immunotherapy, environmental controls, and pharmacologic therapy can help manage allergic diseases.