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Related Concept Videos

Membrane Domains01:18

Membrane Domains

8.3K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
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What are Membranes?01:54

What are Membranes?

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A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and...
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What are Membranes?01:24

What are Membranes?

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A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries...
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What are Membranes?01:24

What are Membranes?

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Membrane Fluidity01:26

Membrane Fluidity

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Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
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Membrane Fluidity01:23

Membrane Fluidity

179.4K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
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Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics
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Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics

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Masses in the membranes.

Sandip Suresh1, Anne S Abel1, Brian R Younge2

  • 1Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.

Survey of Ophthalmology
|October 11, 2015
PubMed
Summary
This summary is machine-generated.

A rare case of central nervous system extranodal marginal zone lymphoma mimicking meningioma and hypertrophic pachymeningitis in a lupus patient is presented. This highlights the importance of re-evaluating initial biopsies for accurate lymphoma diagnosis.

Keywords:
CNS MALT lymphomaEMZLdural lymphomahypertrophic pachymeningitismultiple meningiomasystemic lupus erythematosus

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Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients
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Area of Science:

  • Neurology
  • Oncology
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) can manifest with diverse neurological complications.
  • Dural masses in SLE patients can be challenging to diagnose, mimicking other pathologies.

Observation:

  • A 24-year-old woman with SLE presented with progressive vision loss and cranial nerve deficits.
  • Initial imaging revealed dural masses, leading to a presumed diagnosis of meningioma.
  • Subsequent biopsies showed inflammatory infiltrates, initially diagnosed as hypertrophic pachymeningitis.

Findings:

  • Re-examination of initial biopsies revealed a kappa light chain restricted B-cell and plasmacyte population.
  • This led to a final diagnosis of central nervous system (CNS) extranodal marginal zone lymphoma.
  • The lymphoma mimicked meningioma and inflammatory pachymeningitis over several years.

Implications:

  • This case underscores the critical need for thorough histopathological review in complex neurological presentations of SLE.
  • Accurate diagnosis of CNS lymphoma is crucial for appropriate treatment and improved patient outcomes.
  • It highlights the potential for extranodal marginal zone lymphoma to present insidiously with varied dural manifestations.