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Localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model
Takushi Takata1, Natsuko Kondo2, Yoshinori Sakurai2
1Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan; The Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga-shi, Fukui 914-0192, Japan.
Abstract:
Localized dose delivery techniques to establish a brain radiation necrosis model are described. An irradiation field was designed by using accelerated protons or helium ions with a spread-out Bragg peak. Measurement of the designed field confirmed that a high dose can be confined to a local volume of an animal brain. The irradiation techniques described here are very useful for establishing a necrosis model without existence of extraneous complications.
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