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Materials characterization of explanted polypropylene hernia mesh: Patient factor correlation
Sarah E Smith1, Matthew J Cozad1, David A Grant1
1Department of Bioengineering, University of Missouri, USA.
Journal of Biomaterials Applications
|October 11, 2015
Summary
Polypropylene (PP) hernia mesh shows degradation in vivo. Tobacco use correlated with less PP mesh oxidation and degradation, potentially due to reduced inflammation, aiding patient-matched mesh development.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Polymer Chemistry
Background:
- Polypropylene (PP) hernia mesh is widely used in surgical repairs.
- Understanding in vivo degradation is crucial for improving hernia repair outcomes.
- Patient-specific factors may influence mesh performance and longevity.
Purpose of the Study:
- To quantitatively assess polypropylene hernia mesh degradation.
- To correlate mesh degradation with patient factors like BMI, tobacco use, and diabetes.
- To inform the development of patient-matched hernia mesh for better surgical outcomes.
Main Methods:
- Thirty explanted PP hernia meshes were analyzed.
- Tissue removal followed by Fourier transform infrared, differential scanning calorimetry, and thermogravimetric analysis.
- Results correlated with patient data (BMI, tobacco use, diabetes status).
Main Results:
- Twenty explants exhibited significant surface oxidation.
- Tobacco use correlated with modulated differential scanning calorimetry melt temperature.
- Tobacco use correlated with lower TGA decomposition temperatures, indicating less degradation.
Conclusions:
- Polypropylene hernia mesh undergoes measurable in vivo degradation.
- Tobacco use appears to correlate with reduced mesh oxidation and degradation.
- Findings suggest potential for patient-matched mesh strategies in hernia repair.
