Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Protein Organization

Protein Organization

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical outcomes of patients with diffuse large B-cell lymphoma and concomitant rheumatoid arthritis: a nationwide Danish register-based cohort study.

EULAR rheumatology open·2026

Same author

PROTOCOL: Utilisation of Genetics and Genomics in Primary Care: Protocol for an Evidence and Gap Map.

Campbell systematic reviews·2026

Same author

Mosaic Chromosomal Alterations Identify Ultra-High Risk Clonal Hematopoiesis in Patients With Lymphoma Undergoing Intensive Chemotherapy.

American journal of hematology·2026

Same author

Development and Validation of a Novel Conditional Event-Free Survival Tool in Diffuse Large B-Cell Lymphoma.

American journal of hematology·2026

Same author

CD20 negativity at the start of second-line therapy predicts a shorter overall survival in B-cell lymphomas.

Blood neoplasia·2026

Same author

A targeted circulating tumor DNA landscape of copy number aberrations in large B-cell lymphomas.

Leukemia·2026

Search research articles

Related Experiment Video

Updated: Apr 1, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Fast and accurate non-sequential protein structure alignment using a new asymmetric linear sum assignment heuristic.

Peter Brown¹, Wayne Pullan¹, Yuedong Yang²

¹School of ICT, Griffith University, Gold Coast, QLD 4222, Australia.

Bioinformatics (Oxford, England)

|October 11, 2015

Summary

SPalignNS, a novel non-sequential protein structure alignment tool, enhances accuracy in protein function classification. It outperforms existing methods on diverse benchmark datasets, improving structure comparison for biological insights.

More Related Videos

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Related Experiment Videos

Last Updated: Apr 1, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Area of Science:

Computational biology
Structural bioinformatics
Protein science

Background:

Protein tertiary structure at near atomic resolution reveals function and evolution.
Structure-function relationships necessitate accurate protein structure comparison tools.
The Protein Data Bank's rapid growth demands efficient computational methods for structure analysis.

Purpose of the Study:

To introduce SPalignNS, a novel non-sequential protein structure alignment tool.
To address the need for fast and accurate computational structure comparison.
To improve protein function classification through enhanced structure alignment.

Main Methods:

SPalignNS utilizes a novel asymmetrical greedy search technique.
The tool was implemented in C++.
Performance was evaluated using benchmark datasets including HOMSTRAD and RIPC.

Main Results:

SPalignNS demonstrated superior alignment accuracy across all tested datasets.
It achieved greater structure overlap coverage and comparable root-mean-squared distance.
The tool showed the highest agreement with reference alignments on challenging datasets.

Conclusions:

SPalignNS offers enhanced accuracy for non-sequential protein structure alignment.
The tool provides a valuable advancement for protein function classification.
SPalignNS is freely available as source code, executable, and web server.