Related Experiment Video
Updated: Apr 1, 2026
04:50
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
1.4K
Bipolar disorder associated with rheumatoid arthritis: A case-control study
Adir Farhi1, Arnon D Cohen2, Ora Shovman1
1Department of Medicine 'B', Zabludowicz center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Journal of Affective Disorders
|October 12, 2015
Summary
Patients with rheumatoid arthritis (RA) showed a higher prevalence of bipolar disorder in initial analysis. However, this association was not significant after accounting for confounding factors like smoking.
Area of Science:
- Rheumatology
- Psychiatry
- Epidemiology
Background:
- Rheumatoid arthritis (RA) is a chronic inflammatory condition linked to systemic comorbidities.
- Emerging data indicates a potential increased prevalence of bipolar disorder among RA patients.
- This study aimed to investigate the association between RA and bipolar disorder.
Purpose of the Study:
- To examine the relationship between rheumatoid arthritis and bipolar disorder.
- To compare the prevalence of bipolar disorder in RA patients versus controls.
- To identify potential confounding factors influencing this association.
Main Methods:
- A case-control study design was employed.
- Utilized Clalit Health Services medical database for patient data.
- Compared RA patients (n=11,782) with age- and gender-matched controls (n=57,973).
- Statistical analyses included Pearson chi-squared test and logistic regression.
Main Results:
- Univariate analysis revealed a higher prevalence of bipolar disorder in RA patients (0.6%) compared to controls (0.4%, p=0.036).
- Multivariate analysis indicated no significant association between RA and bipolar disorder.
- Smoking status was significantly correlated with bipolar disorder (p<0.001).
Conclusions:
- Initial findings suggest a higher prevalence of bipolar disorder in RA patients.
- The observed association may be confounded by smoking status.
- Further research is necessary to clarify the clinical implications of this association.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
16.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.7K
01:30Bipolar Disorder
1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
1.0K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.0K
01:23Rheumatic Heart Disease I: Introduction
868
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
868
01:29Autoimmune Disorders
2.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.2K
01:20The JAK-STAT Signaling Pathway
13.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.9K