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Peripheral neuropathy in Parkinson's disease
Zuzana Grambalova1, Michaela Kaiserova1, Miroslav Vastik1
1Department of Neurology, Faculty of Medicine and Dentistry, Palacky University Olomouc, and University Hospital Olomouc, Center for the Diagnosis and Treatment of Neurodegenerative Diseases, Olomouc, Czech Republic.
Neuro Endocrinology Letters
|October 12, 2015
Summary
Parkinson's disease patients show a significantly higher frequency of peripheral neuropathy (PN) compared to controls. This study found 45% of Parkinson's patients had PN, suggesting a neurodegenerative link.
Area of Science:
- Neurology
- Neuroscience
- Clinical Electrophysiology
Background:
- Peripheral neuropathy (PN) is increasingly reported in Parkinson's disease (PD) patients.
- Previous research indicates a potential link between PD and PN.
- This study aimed to confirm the elevated prevalence of PN in PD.
Purpose of the Study:
- To verify the increased frequency of peripheral neuropathy in Parkinson's disease patients.
- To compare PN rates in PD patients against an age-matched control group.
- To explore potential correlations between PN and L-DOPA treatment, PD duration, or age.
Main Methods:
- Electromyography (EMG) including conduction studies and needle EMG were performed.
- 49 PD patients with asymptomatic polyneuropathy and 40 controls were examined.
- Patients and controls without risk factors for PN were selected; blood tests excluded other causes.
Main Results:
- Peripheral neuropathy was significantly more frequent in PD patients (45%) than in controls (2%) (p<0.0001).
- No correlation was found between PN and L-DOPA treatment duration or dosage in PD patients.
- Age or duration of Parkinson's disease did not correlate with PN frequency.
Conclusions:
- The high prevalence of PN in PD patients suggests an underlying neurodegenerative process.
- Both central and peripheral nervous systems appear to be affected in Parkinson's disease.
- Further research may elucidate the specific mechanisms linking PD and PN.
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