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Right ventricular systolic dysfunction and its prognostic value in heart failure with preserved ejection fraction
Acta Cardiologica
|October 13, 2015
Summary
Right ventricular systolic dysfunction (RVSD) significantly increases mortality in heart failure with preserved ejection fraction (HFPEF). This condition is an independent predictor of death in HFPEF patients, highlighting its clinical importance.
Area of Science:
- Cardiology
- Heart Failure Research
Background:
- Right ventricular systolic dysfunction (RVSD) is not well understood in heart failure with preserved ejection fraction (HFPEF).
- Assessing RVSD's impact is crucial for managing HFPEF patients.
Purpose of the Study:
- To evaluate the prevalence of RVSD in HFPEF patients.
- To determine the prognostic significance of RVSD in HFPEF.
Main Methods:
- A pilot study included 95 heart failure patients, categorized by left ventricular ejection fraction (LVEF) into HFPEF (LVEF >40%) and HFREF (LVEF ≤40%).
- RVSD was defined as a peak systolic tricuspid annular velocity (S') <10.8 cm/s.
- Patients were followed for 12 months for mortality outcomes.
Main Results:
- RVSD prevalence was 22% in HFPEF versus 59% in HFREF.
- HFPEF patients with RVSD had higher one-year all-cause mortality (41.7% vs. 4.8%) and cardiovascular mortality (33.3% vs. 0%) compared to those with normal RV function.
- RVSD was identified as the sole independent predictor of one-year all-cause mortality in HFPEF (HR 11.5).
Conclusions:
- RVSD is a significant independent predictor of mortality in HFPEF.
- The presence of RVSD in HFPEF patients is associated with substantially increased one-year all-cause and cardiovascular mortality.
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