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Using aortic distensibility index to detect coronary stenosis
Acta Cardiologica
|October 13, 2015
Summary
Non-invasive aortic distensibility measurements can predict significant coronary artery disease. Lower aortic distensibility index values indicate more severe obstructive coronary artery disease and higher coronary artery calcium scores.
Area of Science:
- Cardiovascular Imaging
- Vascular Function Assessment
Background:
- Aortic distensibility index (ADI) is a vascular function marker.
- ADI may indicate coronary artery disease (CAD) severity.
Purpose of the Study:
- To assess the feasibility of using non-invasively measured ADI as an indicator of coronary stenosis severity.
- To explore the relationship between ADI and CAD severity.
Main Methods:
- 100 patients with normal left ventricular systolic function were enrolled.
- Aortic distensibility was measured using computed tomographic angiography (CTA) and transthoracic echocardiography (TTE).
- Coronary artery disease severity and coronary artery calcium score were assessed.
Main Results:
- A significant inverse correlation was observed between ADI (CTA) and age, systolic blood pressure, coronary artery calcium score, and percent luminal stenosis.
- A strong direct correlation was found between ADI measured by CTA and TTE (r=0.325, P=0.004).
- An echocardiography-derived ADI of 6.65% predicted significant CAD (≥50% luminal stenosis) with 83% sensitivity and 93% specificity.
Conclusions:
- Non-invasive assessment of ADI is feasible for predicting significant atherosclerotic coronary artery disease.
- Lower ADI values are associated with significant obstructive coronary artery disease and high coronary artery calcium scores.
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