Related Experiment Video
Updated: Apr 1, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Mucopolysaccharidosis: radiographic findings in a series of 16 cases
Dmitry José de Santana Sarmento1, Sérgio Henrique Gonçalves de Carvalho1, Saulo Leonardo Sousa Melo2
1Department of Dentistry, Paraíba State University, Araruna, Paraíba, Brazil.
Objectives:
To investigate the radiographic findings of mucopolysaccharidoses (MPS) on panoramic radiographs in a series of 16 patients.
Study Design:
This retrospective cross-sectional study included panoramic radiographs of 16 patients with cytogenetically diagnosed MPS. Two blinded, previously calibrated observers evaluate the presence or absence of the following features: type of dentition; stage of dental age in comparison with chronologic age; delayed exfoliation of deciduous teeth; supernumerary teeth; teeth impaction; enlarged, cyst-like dental crypt; hypercementosis; taurodontism; generalized enamel hypoplasia; enlargement of the bone marrow spaces; thinning of cortical bone; unusual morphology of condyles; and flattening of the condylar head.
Results:
The final sample was composed of 8 MPS IV, 7 MPS VI, and 1 MPS I cases. All patients presented unusual morphology of condyles. Cyst-like dental crypt (75%), taurodontism, and teeth impaction (68.75% each) were also overall common findings. Generalized enamel hypoplasia was exclusively identified in patients with MPS IV (75% of those patients).
Conclusions:
Radiographic features of oral and maxillofacial manifestations in patients with MPS frequently encountered by dentists may help recognize the disorder. However, because of sample size limitations, it was not possible to infer any statistical relationship between the radiographic features and the types of MPS.
Insights
Panoramic radiographs revealed common oral and maxillofacial findings in mucopolysaccharidoses (MPS) patients, including condyle abnormalities and cyst-like dental crypts. These dental radiographic features may aid in recognizing MPS disorders.
Area of Science:
- Dentistry
- Medical Imaging
- Genetics
Background:
- Mucopolysaccharidoses (MPS) are rare genetic disorders.
- Oral and maxillofacial manifestations are common in MPS patients.
- Radiographic evaluation is crucial for diagnosis and management.
Purpose of the Study:
- To investigate radiographic findings on panoramic radiographs in patients with mucopolysaccharidoses (MPS).
- To identify common oral and maxillofacial features associated with MPS.
Main Methods:
- Retrospective cross-sectional study of 16 patients with cytogenetically diagnosed MPS.
- Evaluation of panoramic radiographs for specific dental and skeletal features by two blinded observers.
- Assessment included dentition, dental age, tooth impaction, taurodontism, and condyle morphology.
Main Results:
- All 16 patients exhibited unusual condyle morphology.
- Common findings included cyst-like dental crypts (75%), taurodontism, and tooth impaction (68.75% each).
- Generalized enamel hypoplasia was specific to MPS IV (75% of MPS IV patients).
Conclusions:
- Radiographic features in the oral and maxillofacial region are frequent in MPS patients.
- Dentists may recognize MPS through these common radiographic findings.
- Statistical relationships between specific radiographic features and MPS subtypes could not be established due to sample size.
More Related Videos
Related Concept Videos
01:20Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:23Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...