Molecular mechanisms underlying anticancer effects of myricetin

Area of Science:

• Phytochemistry
• Molecular Biology
• Oncology

Background:

• Myricetin is a common herbal flavonoid with recognized health benefits.
• Emerging research indicates myricetin's potential in combating human diseases, including cancer.
• It influences critical cancer hallmarks like proliferation, apoptosis, and metastasis.

Purpose of the Study:

• To critically review the literature on myricetin's anticancer effects.
• To identify the specific molecular targets responsible for myricetin's anti-cancer activity.

Main Methods:

• Literature review of scientific studies on myricetin and cancer.
• Analysis of molecular interactions and pathways affected by myricetin.

Main Results:

• Myricetin modulates cancer hallmarks such as cell proliferation, signaling pathways, apoptosis, angiogenesis, and metastasis.
• It interacts with oncoproteins including protein kinase B (PKB) (Akt), Fyn, MEK1, and JAK1-STAT3.
• Myricetin exhibits antimitotic effects by targeting cyclin-dependent kinase 1 (CDK1) in liver cancer and induces cell death via mitochondrial pathways.

Conclusions:

• Myricetin demonstrates broad-spectrum anticancer activity through diverse molecular targets.
• Its ability to interact with key oncoproteins and pathways makes it a promising candidate for cancer treatment development.
• Further research into myricetin's molecular mechanisms can pave the way for novel therapeutic strategies.