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Pistacia Terebinthus Coffee Protects against Thioacetamide-Induced Liver Injury in Rats
Ibrahim Halil Bahcecioglu1, Murat Ispiroglu2, Mehmet Tuzcu3
1Department of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey. ihbahcecioglu@yahoo.com.
Aim/Background:
Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats.
Materials And Methods:
Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively.
Results:
After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p PTC intake reduced transforming growth factor beta (TGF-β) concentrations in the liver (p PTC intake.
Discussion And Conclusion:
PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway.
