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Cord blood processing by a novel filtration system.

N Sato1, C Fricke2, C McGuckin3

  • 1Medical Devices Division, Kaneka Corporation, Osaka, 530-8288, Japan.

Cell Proliferation
|October 13, 2015
PubMed
Summary

A new filter device enables gentle, gravity-led processing of cord blood (CB), improving cell recovery and viability. This non-centrifugal method enhances cord blood banking and regenerative medicine applications.

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Area of Science:

  • Biotechnology
  • Hematology
  • Regenerative Medicine

Background:

  • Cord blood processing traditionally relies on centrifugation, limiting accessibility and often resulting in low cell yields.
  • Existing methods require electrical power, posing challenges for widespread cord blood banking and transplantation.

Purpose of the Study:

  • To develop and characterize a novel filter device for cord blood processing using gentle gravity-led flow.
  • To overcome the limitations of centrifugal techniques and improve cell product yield and quality.

Main Methods:

  • Cord blood was processed using the CellEffic CB filter device without centrifugation.
  • Cells were harvested using HES or saline solution.
  • Analysis included differential cell counts, viability, Fluorescence-Activated Cell Sorting (FACS), and clonogenic assays.

Main Results:

  • The filter effectively depleted red blood cells while preserving total nucleated cells, mononuclear cells, CD34+ cells, and hematopoietic precursor cells.
  • Processing performance was consistent with both HES and saline solutions.
  • Gravity-led flow protected the stem cell compartment, with notable maintenance of post-thaw colony forming unit output.

Conclusions:

  • The CellEffic CB filter offers a non-electrical, non-centrifugal solution for cord blood processing.
  • This novel device enables rapid, gentle processing, preserving essential stem and progenitor cells for therapeutic applications.
  • The technology supports advancements in cord blood banking and regenerative medicine.