Related Experiment Video
Updated: Apr 1, 2026
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Levels of High-Density Lipoprotein Cholesterol are Associated With Biomarkers of Inflammation in Patients With Acute
Héctor González-Pacheco1, Luis M Amezcua-Guerra2, Armando Vazquez-Rangel3
1Coronary Care Unit, National Institute of Cardiology, Mexico City, Mexico.
Insights
In acute coronary syndrome (ACS) patients, very low high-density lipoprotein cholesterol (HDL-C) is linked to higher inflammation markers like hs-CRP and lower albumin. These inflammatory markers independently predict very low HDL-C levels in ACS.
Area of Science:
- Cardiology
- Clinical Biochemistry
- Inflammation Research
Background:
- Inflammation is inversely correlated with high-density lipoprotein cholesterol (HDL-C) in various pathologic conditions.
- Understanding this relationship in acute coronary syndrome (ACS) is crucial for risk stratification and management.
Purpose of the Study:
- To investigate the association between very low HDL-C levels and inflammatory biomarkers in patients with ACS.
- To identify independent predictors of very low HDL-C levels in this patient population.
Main Methods:
- A cross-sectional study involving 6,134 patients diagnosed with ACS.
- Patients were categorized based on HDL-C levels: very low (<30 mg/dl), low (30-39.9 mg/dl), and normal (≥40 mg/dl).
- Serum levels of high-sensitivity C-reactive protein (hs-CRP), albumin, and white blood cell count were analyzed at admission.
Main Results:
- 18.5% of ACS patients presented with very low HDL-C levels.
- Patients with very low HDL-C exhibited significantly higher hs-CRP and lower albumin levels compared to those with low or normal HDL-C.
- Low serum albumin (≤3.5 g/dl) and elevated hs-CRP (≥10 mg/L) were identified as independent predictors of very low HDL-C.
Conclusions:
- Very low HDL-C levels in ACS patients are independently associated with elevated hs-CRP and reduced serum albumin.
- These findings highlight the interplay between lipid metabolism and inflammation in ACS.
- The study suggests potential for using inflammatory markers to identify ACS patients at risk for very low HDL-C.
Abstract:
Pathologic conditions associated with inflammation show an inverse correlation between high-density lipoprotein cholesterol (HDL-C) and inflammatory biomarker levels. Our aim was to investigate, in patients with acute coronary syndrome (ACS), whether very low HDL-C levels are associated with inflammatory biomarkers. In a cross-sectional study, we included 6,134 patients with ACS; they were classified as having very low (<30 mg/dl), low (30 to 39.9 mg/dl), and normal HDL-C (≥ 40 mg/dl) levels. We analyzed the association of different categories of HDL-C levels with serum levels of inflammatory biomarkers, high-sensitivity C-reactive protein (hs-CRP), albumin, and white blood cell count at admission. Overall, 18.5% of patients had very low HDL-C levels. Patients with very low HDL-C levels, compared to patients with low or normal HDL-C levels, had the highest hs-CRP (median 17.8 [interquartile range 7.2 to 54.5] vs 12.6 [5.6 to 33.9] vs 12.0 [5.4 to 36.9] mg/L, respectively, p <0.001) and the lowest albumin levels (median 3.6 [IQR 3.3 to 4.0] vs 3.8 [3.5 to 4.0] vs 3.8 [3.5 to 4.1] g/dl, respectively, p <0.001). White blood cell count did not differ significantly (p = 0.40). The multivariate analysis showed that albumin ≤ 3.5 g/dl (odds ratio 2.16, 95% confidence interval 1.88 to 2.49, p <0.001) and hs-CRP ≥ 10 mg/L (odds ratio 1.35, 95% confidence interval 1.17 to 1.55, p <0.001) were independent predictors of very low HDL-C levels. Patients with very low HDL-C levels had the highest inhospital mortality rates compared with the other groups. In conclusion, in patients with ACS, hs-CRP and serum albumin were associated independently with very low HDL-C levels.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
09:41Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:38Inflammation
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:30Coronary Artery Disease I: Introduction
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...