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Updated: Apr 1, 2026
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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
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Controlled Drug Delivery: Historical perspective for the next generation
Yeon Hee Yun1, Byung Kook Lee1, Kinam Park2
1Purdue University, Departments of Biomedical Engineering and Pharmaceutics, West Lafayette, IN 47907, U.S.A.
Summary
Drug delivery technology has evolved through three generations, with the latest focusing on overcoming biological barriers. Future success depends on addressing physiological limits and accelerating development through innovation.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Materials Science
Background:
- Drug delivery systems have evolved significantly since the 1950s.
- The first generation (1950-1980) focused on physicochemical challenges in oral and transdermal formulations.
- The second generation (1980-2010) faced difficulties with biological barriers, limiting clinical success.
Observation:
- Third-generation drug delivery systems (post-2010) must address both physicochemical and biological challenges.
- Physicochemical issues include poor drug solubility and controlling release kinetics for large molecules.
- Biological barriers involve systemic distribution, targeted delivery, and in vivo formulation interactions.
Findings:
- Controlled drug release systems can manage physicochemical properties but not biological barriers.
- Overcoming biological barriers is crucial for effective drug delivery.
- Addressing physiological limitations is key for future advancements.
Implications:
- Future drug delivery systems must integrate solutions for both material science and biological challenges.
- Innovation in drug delivery is essential to overcome physiological limitations.
- Accelerated development through novel approaches will drive the field forward.
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