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Symplastic Glomus Tumor.
Fevziye Kabukçuoğlu1, Hanife Özkayalar, Damlanur Sakiz
1Department of Medical Pathology, Şişli Etfal Education and Research Hospital, İSTANBUL, TURKEY.
Turk Patoloji Dergisi
|October 13, 2015
Summary
Symplastic glomus tumors, rare tumors with atypical cells but benign behavior, require careful differentiation from malignant counterparts. This case highlights their unique presentation and diagnostic considerations.
Area of Science:
- Pathology
- Oncology
Background:
- Glomus tumors are benign neoplasms originating from glomus bodies.
- Symplastic glomus tumors are a rare variant characterized by nuclear pleomorphism without other malignant features.
Observation:
- A 37-year-old woman presented with a tender nodule on her left fourth fingertip, exacerbated by cold exposure.
- Histopathological examination revealed a 0.5 cm lesion with epithelioid cells exhibiting high-grade nuclear pleomorphism, alongside areas typical of glomus tumors.
Findings:
- Immunohistochemistry confirmed smooth muscle actin, caldesmon, and vimentin expression.
- The Ki-67 labeling index was undetectable, and type IV collagen investment was noted.
Implications:
- Symplastic glomus tumors, despite atypical morphology, exhibit benign clinical behavior.
- Accurate differentiation from malignant tumors is crucial for appropriate patient management.
